OX40L-OX40 interactions: A possible target for gastrointestinal autoimmune diseases

OX40-OX40L interactions: a promising therapeutic target for allergic diseases?

Recent advances in understanding the cellular and molecular mechanisms of atopy have shed light on potential targets for the development of new therapies for allergic diseases. In this issue of the JCI, Seshasayee et al. provide direct in vivo evidence that OX40 has critical roles in allergic inflammation mediated by thymic stromal lymphopoietin (TSLP) (see the related article beginning on page...

P 86: CD166 as a Therapeutic Target in Autoimmune Diseases

About 3 decades ago CD6 identified as one of the first antigens expresses on the majority of T cells and a subset of B cells. CD6 regulates cellular adhesion migration across the endothelial and epithelial cells. In recent years researches indicate its role in pathogenesis of autoimmune diseases. Many researches have been done in recent years to block CD6 by CD6 mono clonal antibodies, IOR-T1 a...

Induces Autoimmune-Like Diseases Constitutive OX40/OX40 Ligand Interaction

OX40:OX40L Axis: Emerging Targets for Immunotherapy of Human Disease

Recent advances in our understanding of the mechanisms through which T cells are activated have led to new therapeutic approaches in the treatment of immunological disorders. An emerging target for selective immune intervention has been the manipulation of T cell costimulatory pathways. Impressive results in animal models have shown that the tumor-necrosis-factor receptor (TNFR) family member, ...

OX40/OX40L axis: not a friend in autoimmunity

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by a loss of tolerance toward nuclear components, and multiple organs such as kidney, brain, vessels or skin are affected. SLE presents a waxing and waning course, rendering its outcome hardly predictable. A better understanding of human SLE pathogenesis is direly needed because only few effective treatments are av...